Abstract： Objective To investigate the application value of laparoscopic natural orifice specimen extraction surgery(NOSES)based on purse-string suture for sigmoid colon and upper rectal cancer.Methods The retrospective and descriptive study was conducted.The clinicopathological data of 14 patients undergoing laparoscopic NOSES based on purse-string suture for sigmoid colon and upper rectal cancer in The First Affiliated Hospital of Sun Yat-sen University from October 2022 to June 2023 were collected.There were 8 males and 6 females,aged(56±10)years.Observation indicators:(1)surgical conditions;(2)postoperative conditions;(3)follow-up.Measurement data with normal distribution were represented as Mean±SD.Count data were described as absolute numbers.Results(1)Surgical conditions.All patients underwent laparoscopic NOSES based on purse-string suture for sigmoid colon and upper rectal cancer successfully,without conversion to open surgery.The operation time of 14 patients was(162±32)minutes,and the volume of intraoperative blood loss was(22±12)mL.(2)Postoperative conditions.Time to postoperative first out-of-bed activity,time to postoperative first flatus,time to postoperative first drinking,time to postoperative initial liquid food intake,duration of postoperative hospital stay of 14 patients were(1.6±0.7)days,(2.1±0.6)days,(2.4±0.6)days,(3.8±1.0)days,(6.0±0.9)days,respectively.None of patient had perioperative compli-cations such as postoperative anastomotic leakage and bleeding.(3)Follow-up.All 14 patients were followed up for(9.7±1.9)months.There was no postoperative recurrence,metastasis or death in 14 pati-ents.Conclusion The laparoscopic NOSES based on purse-string suture can be used for sigmoid colon and upper rectal cancer,which is safe and feasible.