检索历史 清除

激素定量检测的准确性一直备受临床和检验专业人员关注。人体内大多数小分子激素存在浓度低、结构类似等特点，需高灵敏度、高特异度的检测技术实现其准确定量。近20年来，液相色谱-串联质谱技术因其独特的灵敏度和特异度优势逐渐从科研走向临床检验，被认为是对传统免疫学方法的有力补充，并在临床疾病诊疗方面不断取得重要成果。为深入探讨质谱技术在激素定量检测中的应用价值，中华检验医学杂志特邀来自临床内分泌学、检验医学领域的专家，围绕质谱技术在临床激素检测中的性能特征、面临的挑战及未来发展方向等总结其经验和看法。专家们一致认为，质谱技术在激素检测中的优势已非常清晰，有效解决了临床在内分泌疾病诊疗时的一些需求，但仍面临着人才储备不足、样本检测通量低、运营成本高且缺乏规范化管理等一系列挑战。

The accuracy of quantitative hormone testing has been concerned by clinical and laboratory professionals. Most of the small molecule hormones in human body have the characteristics of low concentration and similar structure, and need to be detected by high sensitivity and high specificity detection technology to achieve accurate quantification. In the past 20 years, liquid chromatography-tandem mass spectrometry (LC-MS) has gradually moved from scientific research to clinical application because of its unique sensitivity and specificity, which is considered to be a powerful supplement to traditional immunological methods, and has continuously achieved important fruits in clinical disease diagnosis and treatment. In order to further explore the application value of mass spectrometry technology in the quantitative detection of hormones, the Chinese Journal of Laboratory Medicine invited experts from the fields of clinical endocrinology and laboratory medicine to summarize their experience and opinions on the performance characteristics, challenges and future development direction of mass spectrometry technology in clinical hormone testing. Experts agreed that the advantages of mass spectrometry technology in hormone testing have been very clear, could effectively solve some clinical challenges in the diagnosis and treatment of endocrine diseases, but still faces a series of challenges such as insufficient talent reserve, low sample throughput, high operating costs and lack of standardized management.