线粒体转移在脊髓损伤治疗中的研究进展
Recent advance in role of mitochondrial transfer in spinal cord injury
脊髓损伤(SCI)后线粒体功能障碍是造成脊髓继发性损伤的重要病理机制。有研究表明,线粒体转移在损伤后的神经再生过程中发挥着重要作用,线粒体向损伤部位神经元转移后主要通过增强受损神经元的能量代谢水平和减少氧化应激等机制来发挥作用。本文主要对线粒体转移的潜在机制、转移后对损伤后神经再生的影响的研究进展进行综述,以期为进一步研究线粒体转移在SCI发生发展中的作用以及在SCI治疗新策略中的潜在应用提供思路。
更多Mitochondrial dysfunction after spinal cord injury (SCI) is recognized as a crucial pathological mechanism for secondary SCI. Studies have indicated that mitochondrial transfer plays a significant role in the process of neural regeneration following injury. After mitochondria migrating to injured neurons, they mainly function via enhancing the energy metabolism level of damaged neurons and reducing oxidative stress. In this article, we present an exhaustive overview on mechanism of mitochondrial transfer, and impact on neural regeneration after mitochondrial transfer so as to provide valuable insights for further exploring the role of mitochondrial transfer in SCI progression and offer innovative perspective on potential therapeutic strategies for SCI.
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