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目的:探究肢端肥大症患者简易生活质量满意度自评分(self-reported brief life quality satisfaction score, Brief-QoL)及其影响因素，了解已获生化缓解患者Brief-QoL持续较低的原因。方法:纳入2012年1月至2020年12月北京协和manbet官网登录 收治的836例肢端肥大症患者，回顾性总结患者的临床表现、生化指标、影像学特征、合并症及心理健康状态与Brief-QoL之间的关系。在已获生化缓解的患者中，分析生活质量高分组与低分组在临床症状及合并症等方面的差异。结果:末次随访时生化指标控制良好的患者总体Brief-QoL较高，但有头痛(低分组为47.8%，高分组为14.9%， P<0.001)、骨关节痛(低分组为69.6%，高分组为19.0%， P<0.001)等症状的患者即使获得生化缓解，其Brief-QoL仍较低。接受联合治疗(低分组为52.4%，高分组为27.5%， P＝0.030)、合并糖尿病或高脂血症是导致患者生活质量下降的重要原因。 结论:Brief-QoL适用于门诊患者的随访，尽早识别影响生活质量的因素并及时给予干预，有助于实现肢端肥大症患者的规范化管理。

Objective:To explore influencing factors of the self-reported brief life quality satisfaction score(Brief-QoL) in patients with acromegaly and understand the persistent low Brief-QoL scores in cases achieving biochemical remission.Methods:This study included 836 acromegaly patients who were hospitalized at Peking Union Medical College Hospital between January 2012 and December 2020. We retrospectively examined how clinical characteristics, biochemical parameters, comorbidities, and symptoms influenced Brief-QoL. Among patients who achieved biochemical remission, differences in clinical symptoms and comorbidities were analyzed between the high and low quality of life groups.Results:Patients with well-controlled biochemical indicators at the last follow-up had generally high Brief-QoL. However, patients with symptoms such as headaches (47.8% in the low-score group vs 14.9% in the high-score group, P<0.001) and joint pain (69.6% in the low-score group vs 19.0% in the high-score group, P<0.001) had low Brief-QoL despite biochemical remission. Receiving combined treatment(52.4% in the low-score group vs 27.5% in the high-score group, P=0.030) and having comorbid diabetes or hyperlipidemia were significant factors leading to decreased quality of life. Conclusion:Brief-QoL is suitable for follow-up of outpatient patients. Early identification of factors affecting quality of life and timely intervention can facilitate the realization of standardized management.