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肝活检是肝病临床诊疗的重要手段，因其有创性不易为患者接受。常用的肝活检主要有经皮或经颈静脉肝脏穿刺途径。超声内镜下肝脏穿刺活检(EUS-LB)作为新出现的肝脏穿刺技术，近年来得到较多的研究和应用，然而在国内开展较少。EUS-LB具有较高的安全性和舒适性、可同时肝脏双叶取样、有足够的取样量等优点，但也存在对硬件和操作者要求高、成本高等不足。现根据近年来的相关研究结果对EUS-LB在临床中的应用进行综述，探讨其优缺点及开展的可行性。

Liver biopsy is an important means of clinical diagnosis and treatment of liver diseases, but it is not easily accepted by patients because of its invasiveness. The most commonly employed liver biopsy approaches are percutaneous or transjugular. Endoscopic ultrasound-guided liver biopsy (EUS-LB), a newly emerging transjugular technique, has been widely studied and applied in recent years, but its application in China is less common. The EUS-LB has the advantages of high safety and comfort, simultaneous sampling of both liver lobes, and adequate sampling volume; however, it also has the disadvantages of high requirements for hardware, operators, and cost. This article reviews the clinical application of EUS-LB in accordance with pertinent research findings from recent years and discusses its advantages, disadvantages, and implementation feasibility.