Oddi括约肌功能障碍动物模型的研究进展
Advances in animal models of sphincter of Oddi dysfunction
Oddi括约肌功能障碍(SOD)是指Oddi括约肌生理功能异常,可引发胆道、胰腺和肝脏等的一系列疾病。目前SOD的相关研究正成为热点,但是其发病机制并不明确,本文将综述国内外关于SOD的文献,分析不同实验动物模型的优劣势,并对药物和手术造模特点进行分析,为今后相关模型建立提供参考。
更多Sphincter of Oddi dysfunction (SOD) refers to the abnormal physiological function of sphincter of Oddi, which causes a series of syndromes in biliary tract, pancreas and liver. At present, the related research of SOD is becoming a hot spot, but its pathogenesis is not clear. This article will review the domestic and international literatures on SOD, review the advantages and disadvantages of experimental animals such as rabbits, dogs and guinea pigs, and analyze the characteristics of drugs and surgical modeling, so as to provide references for future related model establishment.
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