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目的:探讨胃镜联合腹腔镜（双镜联合）治疗早期胃癌的应用情况。方法:采用描述性病例系列研究方法，回顾性收集2020年5月至2022年10月期间于解放军联勤保障部队第九〇〇manbet官网登录 行双镜联合的15例cT1b期胃癌患者病例资料，其中男性9例，女性6例；年龄中位数59（47~76）岁；中位体质指数20.9（18.3~26.2）kg/m 2，病变位于胃小弯侧胃窦7例，胃角8例。所有病例均经活检病理及超声内镜评估，均在同期行内镜黏膜下剥离术（ESD）+腹腔镜下区域淋巴结清扫。观察指标为手术及病理情况、术后情况和随访情况。 结果:本组患者ESD手术操作时间中位数45（30~82）min，腹腔镜淋巴结清扫时间（45.1±8.6）min。淋巴结清扫时的术中失血量中位数30（10~80）ml。13例患者术后水平切缘阴性；其中SM1期4例，均无淋巴结转移；SM2期9例，其中分别有1例因区域淋巴结阳性、2例因ESD标本脉管阳性（淋巴结阴性）追加标准远端胃大部D 2根治术，切除标本未发现淋巴结转移；另外2例垂直切缘阳性，均同期行标准远端胃大部D 2根治术，其中1例发现淋巴结阳性（第3组，1枚）。双镜治疗术后出现胃排空障碍4例，经对症治疗后均恢复良好；可疑淋巴漏1例，保守处理后治愈；无术后出血、腹腔感染、切口感染病例。中位随访14（6~26）个月，所有病例均未发现肿瘤复发及转移，有3例患者术后3~6个月营养评分为B级，均为胃大部切除手术患者；2例双镜手术患者自述术后反酸、嗳气较术前次数增加。 结论:双镜联合技术治疗早期胃癌是安全可行的，值得临床探索。

Objective:To investigate the application of combined gastroscopy and laparoscopy (dual scope) in the treatment of early gastric cancer.Methods:In this descriptive case series study, we retrospectively collected data on 15 patients with cT1b stage gastric cancer who had undergone combined laparoscopic and endoscopic surgery in the 900th Hospital of the People's Liberation Army of China from May 2020 to October 2022. The study cohort comprised nine men and six women of median age 59 (range: 47–76) years and median body mass index 20.9 (range: 18.3–26.2) kg/m 2. Seven of the lesions were located on the lesser curvature of the gastric antrum and eight in the gastric angle. All lesions were biopsied for pathological examination and evaluated by endoscopic ultrasonography, followed by endoscopic submucosal dissection (ESD) and laparoscopic regional lymph node dissection. Studied variables included surgical and pathological features, postoperative factors, and outcomes. Results:In this group of patients, the median (range) operative time for ESD was 45 (30–82) minutes, the duration of laparoscopic lymph node dissection (45.1±8.6) minutes, and the median (range) intraoperative blood loss during lymph node dissection 30 (10–80) mL. Of the 13 patients with negative postoperative horizontal margins, four were stage SM1 and had no lymph node metastases (Stage SM1) and nine were Stage SM2, of which had one positive regional lymph node and two received additional standard distal gastrectomy with D2 lymphadenectomy concurrently because of positive ESD specimens (lymph node negative). No lymph node metastases were found in the surgical specimens of these patients. The remaining two patients had positive vertical margins; both had undergone concurrent standard distal gastrectomy with D2 lymphadenectomy. One of them was found to be lymph node positive (No. 3, one node). Four patients had impaired gastric emptying after dual-scope treatment, all of whom recovered well with symptomatic management; one patient with a suspected lymphatic leak was also managed conservatively. There were no cases of postoperative bleeding, abdominal infection, or incisional infection. At a median follow-up of 14 (6–26) months, no tumor recurrence or metastasis had been identified in any of the patients. Three patients had a grade B nutrition score 3 to 6 months after surgery, all of whom had undergone major gastrectomy, and two patients who had undergone dual-scope surgery reported an increase in acid reflux and belching after surgery compared with the preoperative period.Conclusion:A combined technique is safe and feasible for the treatment of early gastric cancer and is worthy of further exploration.