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虽然功能型便秘的发病率较高,但目前国内外对其总体的治疗效果仍不满意.对于功能型便秘的诊断和治疗仍较为局限于结肠本身.功能型便秘涉及肠道菌群、 肠自主神经和中枢神经系统间复杂的交互作用.患者存在不同程度的精神和心理等脑功能障碍的表现,脑功能的异常可导致结肠动力、分泌及免疫功能的紊乱;同时,功能型便秘患者存在显著的肠道菌群失衡,肠道菌群对神经递质的释放、下丘脑-垂体-肾上腺轴(HPA轴)的活性起重要作用.肠道菌群是中枢神经系统发育、成熟及活性的重要调节者.因此,认识脑-肠-菌群轴间相互作用可能对于功能型便秘和神经精神性疾病的诊断和治疗提供更为广阔的思路.

Although with the higher prevalence, the overall treatment result of functional constipation is still not satisfied at home and abroad. The diagnosis and treatment of functional constipation are still to focus on colon itself. Functional constipation has complex interactions among intestinal flora, intestinal autonomic nerve and central nervous system. Patients with functional constipation have different degrees of mental and psychological dysfunction , and abnormal brain function can result in disorders of colon dynamics, secretion and immune function. At the same time, there is a significant imbalance of intestinal flora in patients with functional constipation. Intestinal flora plays an important role in the release of neurotransmitter and the activity of hypothalamic-pituitary-adrenal axis (HPA axis). Intestinal flora is an important regulator of development, maturity and activity of central nervous system. Therefore, the interaction in the brain-gut-microbiota axis may provide a broader strategy for the diagnosis and treatment of functional constipation and neuropsychiatric disorder.